Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.For the prevention of cardiovascular disease, statins are a first-line treatment. It is taken by mouth.atovastatin
Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Use during pregnancy may harm the baby. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.atovastatin
The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease:
Hypercholesterolemia(heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson types IIa and IIb) to reduce total cholesterol, LDL-C apo-B, triglycerides levels, and CRPas well as increase HDL levels.
- Heterozygous familial hypercholesterolemia in children
- Homozygous familial hypercholesterolemia
- Hypertriglyceridemia (Fredrickson Type IV)
- Primary dysbetalipoproteinemia (Fredrickson Type III)
- Combined hyperlipidemia
- Primary prevention of heart attack, stroke, and need for revascularization procedures in people who have risk factors such as age, smoking, high blood pressure, low HDL-C, and a family history of early heart disease, but have not yet developed evidence of coronary artery disease.
- Secondary prevention of myocardial infarction, stroke, unstable angina, and revascularization in people with established coronary artery disease.
- Myocardial infarction and stroke prevention in people with type II diabetes
Studies suggest that high-dose statin therapy may play a plaque-stabilizing role in people with acute coronary syndrome and thrombotic stroke.
In people with cardiovascular disease, statins including atorvastatin, do not reduce the risk of kidney failure, but have shown to modestly reduce the progressive decline in kidney function and the severity of protein excretion in urine.Statins, including atorvastatin, before heart surgery do not prevent acute kidney injury
Some statins, including atorvastatin, may help prevent contrast-induced nephropathy in certain groups, such as those with pre-existing kidney impairment There is some evidence to suggest that high-dose statin provides greater benefit compared with regular-dose and low-dose statin in the prevention of contrast-induced acute kidney injury.atovastatin